Despite the therapeutic importance of medicinal plants, toxic substances have been shown to be present in large numbers of plants investigated [3]. Paes-Leme AA, Motta ES, De Mattos JCP. In phase two, three rats were separated into 3 groups of one rat per group. The Pros and Cons of Creatine You Should Know. In a pot, pour in a cup of water and bring to a boil. The plant produces dark green leaves around 8 inches in length. The possible anti-anaemic property of the leaf could be linked to the improved hemoglobin, PCV and RBC observed in this study. Google Scholar. This encourages better flowering and bushier and denser new growth. 217-230. Macrocytic and hypochromic anemia usually results due to increased mean corpuscular volume (MCV) and decrease in mean corpuscular hemoglobin concentration [30]. In subacute study, rats were randomized into six groups of five rats per group: Group 1 (control) received distilled water, group 2, 3, 4, 5, 6 received 50, 100, 500, 800 and 1200mg/kg body weight of J. carnea ethanol extract once daily using oral gavage. 50mg/kg-1200mg/kg treatments relative to control showed varied degree of hepatic injury that is dose dependent. The efficiency of some preexisting anti-obesity drugs was limited by several adverse effects associated with them including gastrointestinal disorder, high risk of cancer, and long-term use detrimental effects on some organs such as liver, kidney and pancreas [ 4, 8 ]. Generally disease free. Side effects of Ewe eje (Justicia carnea leaf Side Effects) Ewe eje is safe and healthy for consumption. leaf inhibits interferon-γ secretion and has bacteriostatic activity against Acinetobacter baumannii and Klebsiella pneumoniae. Join now and start creating your dream garden! The liver and kidney of rats administered with 500mg/kg JCEE and above demonstrated slight increase in MDA level with significant (P<0.05) increase only observed in the liver of rats that received 1200mg/kg of extract. van Andel T., Carvalheiro LG. Estimation of total, protein-bound, and non-protein sulfhydryl groups in tissues with Ellmans reagent. Nigeria's medicinal plant: Justicia carne (Ewe eje) Ewe eje is mainly given to persons who want a blood boost such as pregnant women, persons suffering from anemia and other convalescents. CAS Data were analyzed using one-way analysis of variance (ANOVA) using Statistical Product and Service Solutions (SPSS) version 17.0 and results were expressed as meanSEM. National Research Council. and M.Sc. B-vitamins are good sources of energy. Safety assessment of oral administration of ethanol extract of, $$ \mathrm{Total}\ \mathrm{protein}\kern0.5em =\kern0.5em \frac{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{sample}}{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{standard}}\kern0.5em \times \kern0.5em \mathrm{Concentration}\ \mathrm{of}\ \mathrm{standard} $$, $$ \mathrm{Catalase}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}\right)=\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{SOD}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}/\mathrm{mg}\ \mathrm{protein}\right)\kern0.5em =\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{Concentration}\kern0.5em \mathrm{of}\kern0.5em \mathrm{reduced}\kern0.5em \mathrm{GSH}\kern0.5em =\kern0.5em \frac{\left(\Delta \mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\left(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}\right)} $$, $$ \mathrm{Malondialdehyde}\kern0.5em =\kern0.5em \frac{\left(\mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\Big(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, https://doi.org/10.1186/s40816-020-00234-4, https://doi.org/10.1016/j.jep.2015.06.005, https://doi.org/10.1016/j.joad.2015.08.006, https://doi.org/10.1016/j.jep.2005.06.013, https://doi.org/10.3109/08860220903367585, https://doi.org/10.1590/S0102-695X2011005000196, https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867, https://doi.org/10.35841/biomedicalresearch.30-18-666, https://doi.org/10.1016/j.jep.2007.02.011, https://doi.org/10.1186/s40816-019-0104-4, https://doi.org/10.1016/j.fitote.2008.02.005, https://doi.org/10.1016/j.jada.2008.06.430, https://doi.org/10.1016/j.biocel.2006.07.001, https://doi.org/10.1186/s12906-015-0760-y, http://creativecommons.org/licenses/by/4.0/. Onoagbe IO, Attah V, Luther MM, Esekheigbe A. Hypoglycemic and anti-diabetic effects of Morinda lucida and Tetracera alnifora in normal and streptozotocin-induced diabetic rats. The plant, which is usually green in color and produces pink flowers, belongs to the family of Acanthaceae. The roots and the leaves possess medicinal values and have been used in treating several diseases. Microsomal lipid peroxidation. Eyong EU, Umoh IB, Ebong PE, Eteng MU, Antai AB, Akpa AO. These antibodies help prevent infections and fight off diseases. Water your plants deeply during growth periods, allowing the soil to dry . 1972;47:38994. Create a beautiful garden with this colorful and Use our interactive toolsto design your dream garden. This study has confirmed the safety of ethanol extract of J. carnea leaf and validates its conventional use as blood booster. Control treatment showed normal central venules without congestion, the morphology of the hepatocytes appear normal, the sinusoids appear normal with no observable form of infiltration and no observable pathological lesion seen. It also increases good cholesterol levels. Studies have shown that ewe eje isnt capable of causing damage to the liver. This study investigated the in-vitro antioxidant activity of ethanol leaf extract of Justicia carnea and its effect on antioxidant status of alloxan-induced diabetic albino rats. View abstract. Effect of methanol leaf extract of Justicia carnea on serum albumin (ALB) and total protein (TP) concentration CCl 4 intoxicated rats. The significant decrease in kidney GSH at 1200mg/kg could be due to ample dietary bioactive constituents in the extract that requires frequent conjugation of GSH in the cell or oxidation to oxidized glutathione (GSSG). Justicia pectoralis is a flowering herb that grows in tropical areas of the Americas, including South and Central America. Nunes TRS, Cordeiro MF, Beserra FG, et al. In an acute exposure of experimental rats to single oral doses of extract, no mortality and signs of adverse effects were observed. -Amylase binding-interaction with JCAE was also investigated using fluorescence spectroscopy and molecular docking. The effects of ethanol extract of J. carnea leaf on total protein concentration and antioxidant system in liver and kidney of normal wistar rat is presented in Table 4. -Amylase binding-interaction with JCAE was also investigated using fluorescence spectroscopy and molecular docking. Liver and kidney in all treated groups maintained similar activities of catalase (CAT) compared to the control. The levels of white blood cell count, lymphocyte, granulocyte and MID could indicate that ethanol extract of J. carnea leaf pose no toxicity or sub acute inflammation to the overall defense mechanism and immunity of the experimental rats. This plant is somewhat drought-tolerant once established but looks best with regular watering during periods of extended dry weather. The liver and kidneys excised from all the experimental rats were fixed in a labeled sample bottles containing 10% formalin and processed for histological examination. 2008;108(9):14807. 3 The plants in the family are reported to have CNS effects which are exploited in the management of epilepsy, other mental disorders, headache and fever, probably due to their sedative and analgesic properties. Ewe eje as a Natural Blood booster/tonic: Due to the high concentration of iron in this leaf, it can help boost blood production by increasing the red blood cells, haemoglobin, and the blood platelets. The haematological indices of the blood samples were determined using an automated URIT 2900 Plus 3 Differential Haematological Analyzer. J. Pharmacogn. Part of Decoction of ewe eje or its leaf extract can lower serum cholesterol and get rid of bad cholesterol (LDL). Kone WM, Koffi AG, Bomisso EL, Tra Bi FH. Excitedly, scientific studies have supported the traditional claims. The higher LD50 (>5000mg/kg body weight) of J. carnea leaf ethanol extract suggested that the ethanol extract is experimentally safe and not toxic. Arch Toxicol. Influence of ethanolic extracts of dried fruit of Xylopia aethiopica (Dunal) A. The research work was carried out in collaboration between all authors. Clin Phytosci 2019; 5:9. https://doi.org/10.1186/s40816-019-0104-4. long (20 cm), densely packed with pink to crimson tubular flowers. Local consumers of the leaves are mostly . 2023 BioMed Central Ltd unless otherwise stated. According to acute toxicity grading standards, LD50 of substances greater than 5000mg/kg is practically considered non-toxic [22, 23]. 9 health benefits of justicia carnea - Herbconer From mild to severe order, the graded doses showed distorted renal cortex with collapsed renal glomeruli and dillated capsular spaces. Another strong benefits of justicia carnea leaves is in lipid profile. Justicia Carnea Leaf Benefits - Ewe eje - besthomediet Article This later condition is termed insulin resistance. Watering depends on humidity and temperature. The results of this study suggests that ethanol extract of J. carnea leaf is relatively safe, could be beneficial in alleviating hematology related abnormalities without causing adverse effects on endogenous antioxidant system. Cardioprotective role of Justicia traquebareinsis Linn. Information from this source is evidence-based and objective, and without commercial influence. The absorbance of the supernatant was measured against reagent blank at 532nm. California Privacy Statement, 1983;53:27589. Justicia carnea, the Brazilian plume flower, Brazilian-plume, flamingo flower, or jacobinia, is a flowering plant in the family Acanthaceae. The unique flower clusters and bright coloring has made it a popular choice among landscape artists and amateur gardeners as well. By entering your email address you agree to receive a daily email newsletter from Plant Care Today. Dyslipidemia is one of the risk factors of cardiovascular diseases. Different researches performed on wistar rats has proven the non toxicity of justicia carnea. Be sure to follow relevant directions on product labels and consult your, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. Ani, Onuabuchi & Udedi, Stanley & Asogwa, Kingsley & Enemali, Michael & Onwelumadu, Chigozie & Ikedife, Kenneth. Ewe eje as it is fondly called by the Westerners in Nigeria is a plant known for its blood boosting abilities. He has B.Sc.,and M.Sc. Mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) showed significant (p<0.05) increased at 50mg/kg while doses greater than 100mg/kg showed no significant difference compared to the control. Treatments of all experimental animals were performed following Principle of Laboratory Animal Care manual guidebook of National Institute of Health as approved by the Research Ethics Committee of Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State. Justicia carnea (Brazilian Plume) is an upright, evergreen shrub with large, dark green leaves, 10 in. Cut back after flowering to 2-3 nodes from the ground to keep the plant bushy and promote new blooms. All analyzed dataset to support the conclusions of this article is included as tables in the uploaded supplementary files. Ewe eje isnt capable of causing any side or negative effects if consumed moderately. Justicia pectoralis is a flowering herb that grows in tropical areas of the Americas, including South and Central America. Vitamin B aids in the formation of red blood cells and helps to build tissues. Springer Nature. J Ethnopharmacol. Rats in the 3 different groups received 10, 100 and 1000mg/kg body weight of JCEE orally using oral gavage. Pharm. The lush foliage and distinctive flowers make Brazilian Plume a natural for a . Hence, Justicia carnea can be used to strengthen the immune system. Prepare the existing soil by breaking it up with a spade or hoe. 200, 500 and 1000 mg/kg bw of Justicia carnea showed a significant (p<0.05) decrease in the activities of ALT, AST and ALP, and bilirubin level while total protein and albumin levels increased significantly (p<0.05) when compared with the rats treated with CCl alone. Inter J Pharm Sci Res. 50mg/kg-1200mg/kg treatment relative to control treatment showed varied degree of renal injury that is dose dependent. There may be some problems if the air is too dry in winter. The plant is transplanted in the spring. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. WBC reduced in rats treated with doses of J. carnea with significant decrease (p<0.05) in rats that received 50, 100 and 1200mg/kg body weight. Chemical constituents and biological activities of species of Justicia a review. As reported by science, Justicia carnea is composed of secondary metabolites such as: flavonoids, terpenoids, alkaloids, phenols, saponins and tannins. Buege JA, Aust SD. 2018;2018:5762368. It is not. A total number of forty two (42) male albino rats weighing between 120 and 170g were used in this study. [1] The perennial plant is native to the Atlantic Forest ecoregions of eastern Brazil . Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. It creates the perfect environment for aphids and dried sod. This is why you should avoid potting them if you live in colder areas. Olumese FE, Onoagbe IO, Eze GI, Omoruyi FO. Tietz NW. J Ethnopharmacol. 2010;32(1):1328 https://doi.org/10.3109/08860220903367585. Mr. E.S. 2002;82:197205. Detection of Bioactive Fractions of Justicia Adhatoda L. Leaves The description of these plants has been written based on numerous outside resources. Justicia carnea is amedicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. 2008;79:3326 https://doi.org/10.1016/j.fitote.2008.02.005. Accept Except the group that received 1200mg/kg JCEE which showed significant (p<0.05) elevation of SOD and MDA in the liver, other doses (<1200mg/kg) demonstrated no significant difference compared to the control. https://doi.org/10.1016/j.jada.2008.06.430. Anti-obesity, antioxidant and in silico evaluation of Justicia carnea Duan WL, Liang XM. This suggested that the extract did not alter tissue function in converting harmful hydrogen peroxide to water and oxygen. In these groups, from mild to severe order; the renal cortex appears distorted, Renal glomeruli and dillated capsular spaces appeared collapsed with characteristic pyknosis of the mesangial cells, The renal tubules, interstitial spaces, appears distorted with presence of red inflammatory cells, hemorrhagic cells infiltrating the renal interstitial spaces as well as focal sclerosis of renal glomeruli with associated degeration of the glomerular membrane (red arrows). Kidney weight of rats treated with JCEE showed no significant difference with exception in 800mg/kg JCEE that demonstrated significant reduction. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Inflammation is a complex biological response of body's tissue to harmful stimuli like infections, toxins and itself. Justicia carnea does not cause miscarriage or congenital birth defects. Article Effect of Tectona grandis on phenylhydrazine induced anemia in rats. When you boil the plant, it turns the water red. Not sure which Justicia to pick?Compare All Justicia. Akintimehin is a lecturer in the Biochemistry unit of Chemical Sciences Department, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. At the end of 14th day of administration, rats were allowed to fast overnight, sacrificed to collect samples for biochemical analysis and histopathological examination. Justicia Betonica Herb Uses, Benefits, Cures, Side Effects, Nutrients View abstract. Two of the most important soil considerations include fertility and drainage. Recently, it has also been reported that the species possess cardioprotective properties, antioxidant and are generally rich in vitamins and minerals [10,11,12]. 2004;19(12):16. However, caution should be taken as higher dose at 1200mg/kg could cause noticeable tissue injury. Justicia carnea (Brazilian Plume) - Gardenia.net Phytother Res 2011;25(3):444-450. Yes my readers. 2). long (25 cm), and showy flower plumes, 8 in. While vitamin A maintains good vision, vitamin B are good for cellular functions such as metabolisms and energy production, and improve brain functioning. Tissues were stained with haematoxylin and eosin, mounted on glass slides and examined under a standard light microscope. The renal cortex showed normal glomeruli with mesangial cells and capsular spaces appeared normal (white arrow), the renal tubules appear normal (blue arrow) and interstitial spaces also observed normal (black arrow). Ogwu obara can act as a blood tonic for women during menstruation. View abstract. Powdered sample was extracted using absolute ethanol and concentrated to obtain a slurry paste of J. carnea ethanol extracts. degree in Biochemistry from Olabisi Onabanjo University, Ago-iwoye, and University of Ibadan, Ibadan, Nigeria respectively. Onyeabo C, Achi NK, Ekeleme-Egedigwe CA, Ebere CU, Okoro CK. This is not a big concern as it wont kill the plant and you will find a solution at your local gardening center. Justicia pectoralis might have many different effects in the body. The mixture was allowed to cool and centrifuged at 650g for 10min to obtain the supernatant. Omogunwa is a graduate of Biochemistry from the Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. In winter, you might have to spray the leaves with water, especially if the air is dry. Ren Fail. Justicia carnea is affects Fertility according to a researched article published on ResearchgateJusticia carnea was found to lower sperm count Male Wistar Albino ratsthe effect of this herb on female fertility is not yet known. View abstract. 16. Studies on The Phytochemical and Nutritional if you add justicia carnea leaves in avocado seed tea, you may just get yourself the best remedy for cardiovascular diseases. The cuttings are taken from the parent plant in the spring after the plant has bloomed. Results obtained from the acute oral toxicity study revealed tolerance of experimental rat to acute administration of J. carnea ethanol extracts since no mortality and signs of toxicity were observed after 24h (Table1). In various parts of Africa, several species of Justicia are used in traditional medicine for the treatment of anemia, inflammation, fever, diarrhea, liver diseases and arthritis respiratory and gastrointestinal disorder [8, 9]. Pinch Justicia carnea plants back after theyve flowered. Occupational Health and Safety in the Care and Use of Research Animals. Canadian J Appl Sci. Mr. T.S. The liver and kidneys were excised and rinsed immediately in a normal saline (0.9% Nacl) to remove blood stain, dried between layers of Whatman filter paper, weighed and homogenized to obtain the supernatant for biochemical analysis. Significant (P<0.05) decrease observed in liver total protein of rat administered with 1200mg/kg of extract could be due to intrinsic factors in-vivo that might not necessarily indicate adverse reaction of the extracts. degree in Biochemistry fromUniversity of Ado-Ekiti, Ekiti State, Nigeria and University of Ibadan, Nigeriarespectively. Pot the specimen and bring it indoors to add a bright touch of color to your interiors. 2005 - 2023 WebMD LLC, an Internet Brands company. PubMed 1. SOD is involved in the dismutation of the highly reactive superoxide anion to molecular oxygen (O2) and to less reactive hydrogen peroxides (H2O2) species, whereas CAT removes hydrogen peroxide (H2O2) and toxic hydroxyl radical into water molecule [35]. The genus Justicia named after the 18th-century Scottish botanist James Justice is a flowering plant in the family Acanthaceae. It is commonly referred to as blood root, blood booster, ewe eje in Yoruba, Ogwu obara in Igbo, and jacobinia in Brazil and south America.The plant, which is usually green in color and produces pink flowers, belongs to the family of Acanthaceae. Higher doses (>500mg/kg) of extract significantly (p<0.05) increased RBC, hemoglobin and platelet compared to the control. This could possibly indicate SOD stimulating effects of J. carnea leaf ethanol extract. Chariandy, C. M., Seaforth, C. E., Phelps, R. H., Pollard, G. V., and Khambay, B. P. Screening of medicinal plants from Trinidad and Tobago for antimicrobial and insecticidal properties. Effect of the ethanol extract of Justicia carnea leaves on the red The leaves were able to greatly lower the total cholesterol, LDL-cholesterol, and triglyceride levels, but increased the serum level of high density lipoprotein (HDL) cholesterol. Correspondence to CAS Justicia Carnea leaves extract contains a rich supply of iron, riboflavin, vitamins A, C, E, B1, B2, B9, and B12. Use liquid fertilizers, slow-release or granulated formulas. If you provide us with your name, email address and the payment of a modest $25 annual membership fee, you will become a full member, enabling you to design and save up to 25 of your garden design ideas. Aim. When properly boiled in water, the aqueous leaf extract turns red, and when mixed with milk turns pink. Joseph, H., Gleye, J., Moulis, C., Mensah, L. J., Roussakis, C., and Gratas, C. Justicidin B, a cytotoxic principle from Justicia pectoralis. https://doi.org/10.1016/j.jep.2005.06.013. Wash the Justicia carnea leaves thoroughly to eliminate all forms of insects and dust. WebMD does not provide medical advice, diagnosis or treatment. Onyeabo, Chimaraoke & Achi, Ngozi & Chima, Ekeleme-Egedigwe & Ebere, Chidinma & Okoro, Chidinma. J Ethnopharmacol. Allium satium and Justicia carnea either used alone or co-administered had an ameliorating effect on cadmium toxicity. The shrubby habit of the plant is well-suited for both containers and outside planting. Keep in mind that natural products are not always necessarily safe and dosages can be important. Guide to Jacobinia/Justicia Carnea - How to Grow This Plant - Gardenzy J Ethnopharmacol 1985;13(1):3-49. Emmanuel Sina Akintimehin. However, watch out for nematodes and spider mites. How Justicia Betonica is effective for various diseases is listed in repertory format. It is a creeping, perennial plant and grows up to 2 meters tall. 2019;30(4):64554. Effects of ethanol leaf extract of Justicia carnea on serum SOD The present study investigated the antioxidant and in vitro antidiabetic capacities of Justicia carnea aqueous leaf extract (JCAE) using -amylase inhibition model. The leaves of justicia carnea possess high content of iron and vitamin C. This compounds may be responsible for the blood boosting property of ewe eje leaves. This post was last modified on January 2, 2023 5:23 pm. While the renal tubules across the tested groups were normal with the interstitial spaces showing moderate congestion and hemorrhage, there appeared some abnormalities in the renal cortex (such as few sclerotic glomeruli with moderately dilated capsular spaces) resulting in fair architectural structure of the kidney (Fig. African J Plant Sci. The perennial plant puts on a never-ending show of radiant flowers from early spring to fall. There are several nutritional benefits of justicia carnea leaves. J Ethnopharmacol 2000;70(2):151-159. hindawi publishing corporation evidence-based complementary and alternative medicine. Venancio, E. T., Rocha, N. F., Rios, E. R., Feitosa, M. L., Linhares, M. I., Melo, F. H., Matias, M. S., Fonseca, F. N., Sousa, F. C., Leal, L. K., and Fonteles, M. M. Anxiolytic-like effects of standardized extract of Justicia pectoralis (SEJP) in mice: Involvement of GABA/benzodiazepine in receptor. Organic extract of Justicia pectoralis Jacq. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects.